Effect of Suvorexant vs Placebo on Daytime Sleep in Shift Workers: Randomized Clinical Trial

Effect of Suvorexant vs Placebo on Daytime Sleep in Shift Workers: Randomized Clinical Trial

Type: Randomized controlled trial

Registration: PMCID: PMC7267849

Status: Published

Tags: Medication, Night-shift workers, RCT, Shift Work Disorder (SWD), Sleep

External URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC7267849/

Summary

Double‑blind RCT testing the dual orexin receptor antagonist suvorexant vs placebo showed increased daytime sleep time among shift workers with insomnia complaints.

Why It Matters For Night Shift Workers and Night Owls

This RCT whether wake‑ or sleep‑promoting medications showed sleep & alertness for night‑shift workers and night owls. The effects appear in real shift contexts, clarifying where medicines fit alongside timing strategies instead of replacing them. For people who work nights, that frames an everyday choice (when you eat, how you light the end of a shift, how rest is split) as part of the mechanism, not just routine.

Tags

  • Medication
  • Night-shift workers
  • RCT
  • Shift Work Disorder (SWD)
  • Sleep

Notes

JAMA Network Open trial; focuses on daytime sleep after shifts.

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