Registration: PMCID: PMC12195091
Status: Published
Tags: GI & microbiome, Inflammation, Review
External URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC12195091/
This narrative review compiles research on how night-shift schedules may alter the gut microbiota and contribute to gastrointestinal problems. Studies suggest that disrupted sleep–wake cycles, irregular meal timing, and circadian misalignment can shift gut microbial communities, promoting inflammation and raising risks for conditions like ulcers, IBS, and reflux. However, the evidence remains inconsistent due to small sample sizes, varied study designs, and lack of standardized methods. The review concludes that while dysbiosis appears to be a plausible pathway linking shift work with gut and metabolic disease, larger, better-controlled studies are needed.
The gut microbiome is key for digestion, immunity, and long-term metabolic health. This review highlights how irregular schedules, overnight eating, and poor-quality sleep may destabilize that system—even if the exact patterns aren’t fully proven yet. For shift workers, the takeaway is that consistent meal timing, balanced nutrition, and recovery strategies may help protect gut health until stronger evidence can guide more precise recommendations.
Recent narrative synthesis.