Circadian misalignment and adverse cardiometabolic consequences in humans
Summary
Forced circadian misalignment (shifted sleep/meal schedule) increased glucose, insulin, and BP and reduced leptin—independent of sleep duration.
Why It Matters For Night Shift Workers and Night Owls
Participants randomized in this trial how rotation direction, quick‑returns, and long duties showed blood sugar and blood pressure for night‑shift workers and night owls. Patterns in the data make ‘quick returns’ and rotation direction concrete risk features rather than abstract policy terms. For night‑shift teams and individuals, this ties long‑debated rota features to concrete outcomes, making schedule talk about health, not preference.
Notes
PNAS study in controlled lab conditions.