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Chemical Imbalances in Shift Work

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Chemical Imbalances in Shift Work

Circadian health expert and medical scientist Logan Pendergrast, Ph.D., explains how disrupted sleep patterns and chemical imbalances affect brain function. He describes how suppressed melatonin from artificial light, elevated cortisol near bedtime, and shifts in neurotransmitters such as dopamine, serotonin, and orexin can disturb the body’s natural rhythm. These imbalances not only interfere with deep sleep but also impact mood, motivation, and alertness.
Dr. Pendergrast also highlights the long-term consequences of desynchronized sleep, including reduced reaction time, impaired memory consolidation, and heightened emotional responses driven by hyperactivity in the amygdala. These changes underline how essential it is to maintain synchronized sleep patterns for brain health and overall wellbeing. Simple strategies, such as light physical activity upon waking, can help restore balance and improve resilience against the negative effects of shift work and irregular schedules.

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