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Understanding Key Neurotransmitters in Sleep

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Understanding Key Neurotransmitters in Sleep

Circadian health expert and medical scientist Logan Pendergrast, Ph.D., explains the essential neurotransmitters that regulate sleep and wakefulness. This segment explores adenosine, the chemical behind sleep pressure, and GABA, the brain’s main inhibitory neurotransmitter that fosters calm and rest.
Dr. Pendergrast also highlights orexin, the neurotransmitter responsible for sustaining wakefulness and alertness, and how its deficiency can cause narcolepsy. Finally, he covers serotonin’s dual role in mood and as a precursor to melatonin, the hormone that helps lower body temperature and promote deep, restorative sleep. Together, these chemical messengers create the foundation for the sleep–wake cycle and support healthy brain function throughout the day.

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